Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Structural formula of fluconazole ( A ) and its core ( B ) used for literature search.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Original approaches to fluconazole synthesis based on: the Snieckus direct ortho -lithiation ( a ), the Friedel–Crafts acylation ( b ).

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Improved regioselective synthesis of fluconazole through avoidance of the oxirane intermediate.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Improved synthesis of fluconazole through the utilization of the aminotriazole and oxirane steps.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole using [(1 H -1,2,4-triazol-1-yl)methyl]lithium.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: s -Triazine based synthesis of fluconazole.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole following the Grignard strategy.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: 2,4-Difluorostyrene pathway to fluconazole.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Visible-light-induced synthesis of fluconazole via the regioselective radical oxo-amination step.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Semi-continuous flow synthesis of the key intermediate epichlorohydrin, used in the synthesis of fluconazole.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Site-selective silver-catalyzed C-H bond deuteration of fluconazole.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Mn@Starch-NP mediated protium/deuterium exchange in fluconazole.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques: Starch

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: RuNp@PVP mediated the H/D replacement in the fluconazole molecule.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of 18 F - labeled fluconazole.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques: Labeling

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole analogs using Grignard reagents.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Analog of fluconazole synthesis featuring a trifluoromethyl group at position C-4 of phenyl.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole analogs substituted at one of the methylene moieties with a methyl group.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole analogs with alkoxy substitution at the methylene moiety.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole derivatives containing modifications at the methylene moiety and in the carboaromatic ring.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole analogs with halogens in the carboaromatic ring.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of chiral non-racemic analogs of fluconazole via: cyclization of 1,3-diol ( a ), oxirane formation with Me 3 S(O)I ( b ), epoxidation of alkene ( c ).

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole analogs with a methyl group and different substituents in the carboaromatic ring via: cyclization of enantiopure 1,3-diol ( a ), defluoroamination reaction ( b ).

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of a fluconazole analog containing a 4 H -benzo[ b ][1,4]thiazine unit.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole analog containing a phenoxy group at the 4-position of the carboaromatic ring.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of a 4-fluoro-2-(4-fluorophenoxy)phenyl analog of fluconazole.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of a fluconazole analog containing the 4-(4-chlorophenoxy)phenyl group.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole derivatives substituted at position 3 of the 1,2,4-triazole ring.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of analogs od fluconazole via : acetophenones ( a ), oxirane ( b ), and dibromopropan-2-ols ( c ) key intermediates.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole analogs with an E -styryl- substituent at position 3 ( a ) and at positions 3 or 5 ( b ) of the 1,2,4-triazole moiety.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of a novel fluconazole analog that had one of the 1,2,4-triazole rings substituted with a (E) -4-(2,2,3,3-tetrafluoropropoxy)styryl moiety at position C-3.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of an enantiopure fluconazole derivative.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Alternative synthesis of an enantiopure fluconazole derivative with 2,2,3,3-tetrafluoropropoxystyryl substituted at the 1,2,4-triazole moiety.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of N -substituted carbamoyloxyalkyl-azolium analogs of fluconazole.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of a new triazolethione analog of fluconazole.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of a dansyl–fluconazole conjugate.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of a sordarin–fluconazole conjugate.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of new fluconazole derivatives substituted at the triazole moiety.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole analogs substituted at position 3 of the triazole moiety by a nitro group.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole derivatives substituted at the 3-position of the triazole ring with a nitro group.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of dicationic fluconazole analogs.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of a conjugate of fluconazole with ascomycine.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole analogs decorated with benzylthio groups.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole-based CYP51/HDAC dual inhibitors.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of a 3-mercapto-1,2,4-triazole analog of fluconazole.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of new fluconazole esters obtained from selected acid chlorides.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of phosphate derivatives of fluconazole.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of new fluconazole derivatives using acid chlorides.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of a fluconazole–porphyrin conjugate.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthetic routes to fluconazole benzoic acid esters.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Reaction between fluconazole and cinnamic acid chloride.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of two fluconazole molecules linked by PEG.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of a new fluconazole derivative with an azithromycin moiety.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of cholesterol-fluconazole conjugate.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of a fluconazole hybrid with cholesterol linked with a phosphate group.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole derivatives with different alcohols linked with a phosphate group: with substituents R 1 and R 2 ( a ), with substituents R 1 ( b ), with substituents R 2 ( c ).

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole phosphate.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of O -TMS protected fluconazole.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of a fluconazole analog as ether derivative.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of an analog of fluconazole with fluorine atom instead of hydroxy group.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of fluconazole derivatives without the hydroxy group.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of chloro analogs of fluconazole.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal: Molecules

Article Title: Fluconazole Analogs and Derivatives: An Overview of Synthesis, Chemical Transformations, and Biological Activity

doi: 10.3390/molecules29122855

Figure Lengend Snippet: Synthesis of novel analogs (cyano, azido, and mercapto) of fluconazole at the carbinolic center.

Article Snippet: Rohm and Haas Company patented a method of synthesizing a new ester of fluconazole in the reaction with 1-[(chlorocarbonyl)oxy]-2-oxo-2-[(propan-2-yl)oxy]ethyl 2-methylpropanoate ( ).

Techniques:

Journal:

Article Title: Antifungal Susceptibility Testing of Dermatophytes: Establishing a Medium for Inducing Conidial Growth and Evaluation of Susceptibility of Clinical Isolates

doi:

Figure Lengend Snippet: Mean MICs of fluconazole, itraconazole, terbinafine, and griseofulvin for 217 dermatophytes by the proposed method for in vitro susceptibility testing.

Article Snippet: Fluconazole was dissolved in sterile water, itraconazole and griseofulvin were dissolved in 100% dimethyl sulfoxide (Curtin Matheson Scientific Inc., Houston, Tex.), and terbinafine was dissolved in dimethyl sulfoxide with 5% Tween 80 (Curtin Matheson Scientific Inc., Houston, Tex.).

Techniques: In Vitro

Journal:

Article Title: Antifungal Susceptibility Testing of Dermatophytes: Establishing a Medium for Inducing Conidial Growth and Evaluation of Susceptibility of Clinical Isolates

doi:

Figure Lengend Snippet: MIC 50 s and MIC 90 s of fluconazole, itraconazole, terbinafine, and griseofulvin for 217 dermatophytes

Article Snippet: Fluconazole was dissolved in sterile water, itraconazole and griseofulvin were dissolved in 100% dimethyl sulfoxide (Curtin Matheson Scientific Inc., Houston, Tex.), and terbinafine was dissolved in dimethyl sulfoxide with 5% Tween 80 (Curtin Matheson Scientific Inc., Houston, Tex.).

Techniques: